diff --git a/pre-upload.py b/pre-upload.py
index 5f1f95d..511324d 100755
--- a/pre-upload.py
+++ b/pre-upload.py
@@ -634,13 +634,20 @@
   except ValueError as ex:
     return HookFailure(msg, [example, str(ex)])
   # Check that Cq-Depend is in the same paragraph as Change-Id.
-  msg = 'Cq-Depend (or CQ-DEPEND) is not in the same paragraph as Change-Id.'
+  msg = 'Cq-Depend is not in the same paragraph as Change-Id.'
   paragraphs = desc.split('\n\n')
   for paragraph in paragraphs:
-    if (re.search(r'^Cq-Depend:', paragraph, re.M) or
-        re.search(r'^CQ-DEPEND=', paragraph, re.M)) \
-        and not re.search('^Change-Id:', paragraph, re.M):
+    if (re.search(r'^Cq-Depend:', paragraph, re.M) and not
+        re.search('^Change-Id:', paragraph, re.M)):
       return HookFailure(msg)
+
+  # We no longer support CQ-DEPEND= lines.
+  if re.search(r'^CQ-DEPEND[=:]', desc, re.M):
+    return HookFailure(
+        'CQ-DEPEND= is no longer supported.  Please see:\n'
+        'https://chromium.googlesource.com/chromiumos/docs/+/HEAD/'
+        'contributing.md#CQ-DEPEND')
+
   return None
 
 
diff --git a/pre-upload_unittest.py b/pre-upload_unittest.py
index 62e5d90..f672a7c 100755
--- a/pre-upload_unittest.py
+++ b/pre-upload_unittest.py
@@ -1166,6 +1166,7 @@
     self.assertMessageRejected('\nCq-Depend=chromium=1234\n')
     self.assertMessageRejected('\nCq-Depend: None\n')
     self.assertMessageRejected('\nCq-Depend: chromium:1234\n\nChange-Id: I123')
+    self.assertMessageRejected('\nCQ-DEPEND=1234\n')
 
 
 class CheckCommitMessageContribution(CommitMessageTestCase):